{"id":462,"date":"2025-05-07T17:19:09","date_gmt":"2025-05-07T20:19:09","guid":{"rendered":"https:\/\/ingenieria.uner.edu.ar\/nucleos\/quimica_ambiental\/?p=462"},"modified":"2025-05-07T18:16:56","modified_gmt":"2025-05-07T21:16:56","slug":"morphological-and-functional-alterations-of-zebrafish-danio-rerio-liver-after-exposure-to-two-ecologically-relevant-concentrations-of-lead","status":"publish","type":"post","link":"https:\/\/ingenieria.uner.edu.ar\/nucleos\/quimica_ambiental\/index.php\/2025\/05\/07\/morphological-and-functional-alterations-of-zebrafish-danio-rerio-liver-after-exposure-to-two-ecologically-relevant-concentrations-of-lead\/","title":{"rendered":"Morphological and Functional Alterations of Zebrafish (Danio rerio) Liver after Exposure to Two Ecologically Relevant Concentrations of Lead."},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"462\" class=\"elementor elementor-462\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0524603 e-flex e-con-boxed e-con e-parent\" data-id=\"0524603\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-dced631 elementor-widget elementor-widget-text-editor\" data-id=\"dced631\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<div class=\"pt-lg !text-[18px] font-semibold\"><strong>Abstract<\/strong><\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bc04ff9 elementor-widget elementor-widget-text-editor\" data-id=\"bc04ff9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-size: 1rem;\">Lead (Pb) is a non-essential, highly toxic, and persistent element widely recognised as one of the most concerning pollutants, and it is listed in the Priority List of Hazardous Substances. Widespread environmental contamination from Pb is a serious issue for human health and wildlife. The liver, a key compartment for metal detoxification and excretion, is also the organ in which Pb mainly accumulates in fish. Herein, we investigated for the first time the morphological and functional injuries induced in zebrafish (Danio rerio) liver by two very low and environmentally relevant concentrations of Pb (2.5 and 5 \u03bcg\/L) after 48, 96, and 192 hours of exposure. We showed significant histological alterations in all the exposed samples, also demonstrating that the extent of injuries increased with dose and exposure time. The most common modifications observed were congestion of blood vessels and sinusoids, cytoplasmic vacuolizations, parenchyma dyschromia, and macrophage proliferation. Pb administration also resulted in a significant increase in lipid content and the upregulation of key genes involved in metal detoxification (mtf1) and the defensive response against oxidative stress (sod1 and cat). We showed that even very low doses of Pb can disrupt liver morphology and function.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ad6261e e-flex e-con-boxed e-con e-parent\" data-id=\"ad6261e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b5adfbb elementor-widget elementor-widget-text-editor\" data-id=\"b5adfbb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"pt-lg !text-[18px] font-semibold\"><strong><span style=\"font-size: 1rem;\">Keywords<\/span><\/strong><\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fabd25e elementor-widget elementor-widget-text-editor\" data-id=\"fabd25e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li><div class=\"w-fit inline-block cursor-pointer text-color-link-bold hover:underline hover:text-color-link-bold\">Lead<\/div><\/li><li><div class=\"w-fit inline-block cursor-pointer text-color-link-bold hover:underline hover:text-color-link-bold\"><span style=\"font-size: 16px;\">Liver<\/span><\/div><\/li><li><div class=\"w-fit inline-block cursor-pointer text-color-link-bold hover:underline hover:text-color-link-bold\">Molecular biomarkers<\/div><\/li><li><div class=\"w-fit inline-block cursor-pointer text-color-link-bold hover:underline hover:text-color-link-bold\">Morphological biomarker<\/div><\/li><li><div class=\"w-fit inline-block cursor-pointer text-color-link-bold hover:underline hover:text-color-link-bold\"><span style=\"font-size: 16px;\">MTs<\/span><\/div><\/li><li><div class=\"w-fit inline-block cursor-pointer text-color-link-bold hover:underline hover:text-color-link-bold\">SOD<\/div><\/li><li><div class=\"w-fit inline-block cursor-pointer text-color-link-bold hover:underline hover:text-color-link-bold\"><span style=\"font-size: 16px;\">CAT<\/span><\/div><\/li><\/ul><div>\u00a0<\/div><div>\u00a0<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e1fe466 elementor-widget elementor-widget-button\" data-id=\"e1fe466\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.preprints.org\/manuscript\/202305.1913\/v1\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">VER PUBLICACI\u00d3N<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e276a5f e-flex e-con-boxed e-con e-parent\" data-id=\"e276a5f\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Abstract Lead (Pb) is a non-essential, highly toxic, and persistent element widely recognised as one of the most concerning pollutants, and it is listed in the Priority List of Hazardous Substances. Widespread environmental contamination from Pb is a serious issue for human health and wildlife. The liver, a key compartment for metal detoxification and excretion, [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-462","post","type-post","status-publish","format-standard","hentry","category-publicaciones-publicaciones"],"_links":{"self":[{"href":"https:\/\/ingenieria.uner.edu.ar\/nucleos\/quimica_ambiental\/index.php\/wp-json\/wp\/v2\/posts\/462","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ingenieria.uner.edu.ar\/nucleos\/quimica_ambiental\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ingenieria.uner.edu.ar\/nucleos\/quimica_ambiental\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ingenieria.uner.edu.ar\/nucleos\/quimica_ambiental\/index.php\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/ingenieria.uner.edu.ar\/nucleos\/quimica_ambiental\/index.php\/wp-json\/wp\/v2\/comments?post=462"}],"version-history":[{"count":21,"href":"https:\/\/ingenieria.uner.edu.ar\/nucleos\/quimica_ambiental\/index.php\/wp-json\/wp\/v2\/posts\/462\/revisions"}],"predecessor-version":[{"id":487,"href":"https:\/\/ingenieria.uner.edu.ar\/nucleos\/quimica_ambiental\/index.php\/wp-json\/wp\/v2\/posts\/462\/revisions\/487"}],"wp:attachment":[{"href":"https:\/\/ingenieria.uner.edu.ar\/nucleos\/quimica_ambiental\/index.php\/wp-json\/wp\/v2\/media?parent=462"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ingenieria.uner.edu.ar\/nucleos\/quimica_ambiental\/index.php\/wp-json\/wp\/v2\/categories?post=462"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ingenieria.uner.edu.ar\/nucleos\/quimica_ambiental\/index.php\/wp-json\/wp\/v2\/tags?post=462"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}